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KMID : 0438219780150020123
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Korea University Medical Journal
1978 Volume.15 No. 2 p.123 ~ p.130
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Influences of adrenergic blockades on the hyperglycemic action of ephedrine
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Abstract
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Ephedrine. which is an alkaloid with direct and indirect sympathomimetic property has been well known as a tachyphylactic drug,. but few studies were reported for the metabolic. effect of it,
In this paper, =the change of the hyperglycemic action of ephedrine which was occured by increase of ephedrine dosage or repeated injection of it in rabbits respectively and the influences of several adrenergic blocking drugs on the hyperglycemic action of.ephedrine were investigated. :
The results obtained were as follows:
1. The .increase of; blood -sugar-induced by triple injection of ephedrine 10 mg/kg (repeat interval: 10 min.),twas much_ less than that, induced by each infection-of ephedrine iq mfg kg and 3omg/ ,; kg respectively
1 _2:´:The increase of blood; sugar induced by ephedrine.:was;.significantly _inhibi .by reserpipe_. Pretreatment:´
Th0 blood;sclg r; c9nce Itration was not; increased _bydibenamiIIe 2 mg/kg ut increased -by dibenamine 10 mg/.kg, and the increase of blood sugar.Anduced;-by ephedr~ue vacs ~S~g dficautll potentiated liy.`_aibenamine ;pretrea~ment;of both dosages.
4. The blood `sugar coricentiation -was slightly incrpas0,d by ,ergot# nine o. Yl pg kg _ ut a t JbeTtamlinFPret´trQemtihe=concentrat;on was not:,creased fiy;eped@Lndr,theridgwr eased below the normal level
5. The incre "f-,J? d sugar induced by ephedrine.,and the increase by ephedrine which was_ - potentiated by gibenamine pretreatment were significantly-Juhibited by propr-,agolol.._
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